Differential adapter recruitment by TLR2 co-receptors
نویسندگان
چکیده
منابع مشابه
MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction.
Members of the Toll-like receptor (TLR) family are essential players in activating the host innate immune response against infectious microorganisms. All TLRs signal through Toll/interleukin 1 receptor domain-containing adapter proteins. MyD88 adapter-like (Mal) is one such adapter that specifically is involved in TLR2 and TLR4 signaling. When overexpressed we have found that Mal undergoes tyro...
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www.sciencemag.org (this information is current as of March 16, 2008 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/319/5866/1092 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/1151804/DC1 can be found at: ...
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In mammalian host cells staphylococcal peptidoglycan (PGN) is recognized by Nod2. Whether PGN is also recognized by TLR2 is disputed. Here we carried out PGN co-localization and stimulation studies with TLR2 and Nod2 in wild type and mutant host cells. To exclude contamination with lipoproteins, polymeric staphylococcal PGN (PGN(pol)) was isolated from Staphylococcus aureus Δlgt (lacking lipida...
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ژورنال
عنوان ژورنال: Pathogens and Disease
سال: 2016
ISSN: 2049-632X,2049-632X
DOI: 10.1093/femspd/ftw043